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UniProt functional annotation for A0A059ZPP5 | ||
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| UniProt code: A0A059ZPP5. |
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| Organism: | |
Acinetobacter baumannii. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; Acinetobacter calcoaceticus/baumannii complex. |
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| Function: | |
Converts carnitine to trimethylamine and malic semialdehyde. {ECO:0000256|HAMAP-Rule:MF_02097}. |
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| Catalytic activity: | |
Reaction=(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4- oxobutanoate + H2O + NAD(+) + trimethylamine; Xref=Rhea:RHEA:55396, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16347, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58389, ChEBI:CHEBI:138809; EC=1.14.13.239; Evidence={ECO:0000256|HAMAP-Rule:MF_02097}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4- oxobutanoate + H2O + NADP(+) + trimethylamine; Xref=Rhea:RHEA:55368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58389, ChEBI:CHEBI:138809; EC=1.14.13.239; Evidence={ECO:0000256|HAMAP-Rule:MF_02097}; |
| Cofactor: | |
Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000256|HAMAP-Rule:MF_02097}; Note=Binds 1 Fe cation per subunit. {ECO:0000256|HAMAP-Rule:MF_02097}; |
| Cofactor: | |
Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000256|HAMAP-Rule:MF_02097}; Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000256|HAMAP- Rule:MF_02097}; |
| Pathway: | |
Amine and polyamine metabolism; carnitine metabolism. {ECO:0000256|HAMAP-Rule:MF_02097}. |
| Subunit: | |
Composed of an oxygenase subunit and a reductase subunit. {ECO:0000256|HAMAP-Rule:MF_02097}. |
| Similarity: | |
Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily. {ECO:0000256|HAMAP- Rule:MF_02097}. |
Annotations taken from UniProtKB at the EBI.