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PDBsum entry 6xv0
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Transport protein
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PDB id
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6xv0
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References listed in PDB file
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Key reference
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Title
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Binding of a fatty acid-Functionalized anderson-Type polyoxometalate to human serum albumin.
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Authors
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A.Bijelic,
A.Dobrov,
A.Roller,
A.Rompel.
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Ref.
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Inorg Chem, 2020,
59,
5243-5246.
[DOI no: ]
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PubMed id
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Abstract
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The Anderson-type hexamolybdoaluminate functionalized with lauric acid (LA),
(TBA)3[Al(OH)3Mo6O18{(OCH2)3CNHCOC11H23}]·9H2O
(TBA-AlMo6-LA, where TBA = tetrabutylammonium), was prepared via two
synthetic routes and characterized by thermogravimetric and elemental analyses,
mass spectrometry, IR and 1H NMR spectroscopy, and powder and
single-crystal X-ray diffraction. The interaction of TBA-AlMo6-LA
with human serum albumin (HSA) was investigated via fluorescence and circular
dichroism spectroscopy. The results revealed that TBA-AlMo6-LA binds
strongly to HSA (63% quenching at an HSA/TBA-AlMo6-LA ratio of 1:1),
exhibiting static quenching. In contrast to TBA-AlMo6-LA, the
nonfunctionalized polyoxometalate,
Na3(H2O)6[Al(OH)6Mo6O18]·2H2O
(AlMo6), showed weak binding toward HSA (22% quenching at a
HSA/AlMo6 ratio of 1:25). HSA binding was confirmed by X-ray
structure analysis of the HSA-Myr-AlMo6-LA complex (Myr = myristate).
These results provide a promising lead for the design of novel
polyoxometalate-based hybrids that are able to exploit HSA as a delivery vehicle
to improve their pharmacokinetics and bioactivity.
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