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UniProt functional annotation for Q9UJM8 | ||
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| UniProt code: Q9UJM8. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. {ECO:0000269|PubMed:18215067}. |
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| Catalytic activity: | |
Reaction=a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2; Xref=Rhea:RHEA:16789, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:35179, ChEBI:CHEBI:58123; EC=1.1.3.15; Evidence={ECO:0000269|PubMed:18215067}; |
| Cofactor: | |
Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000255|PROSITE-ProRule:PRU00683, ECO:0000269|PubMed:18215067}; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=141 uM for glycolate {ECO:0000269|PubMed:18215067}; KM=40 uM for 2-hydroxy octanoate {ECO:0000269|PubMed:18215067}; KM=2200 uM for glyoxylate {ECO:0000269|PubMed:18215067}; |
| Pathway: | |
Organic acid metabolism; glycolate degradation; 3-phospho-D- glycerate from glycolate: step 1/4. |
| Subcellular location: | |
Peroxisome. |
| Tissue specificity: | |
Liver. |
| Similarity: | |
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. {ECO:0000255|PROSITE-ProRule:PRU00683}. |
Annotations taken from UniProtKB at the EBI.