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UniProt functional annotation for P9WNX1 | ||
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| UniProt code: P9WNX1. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
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| Catalytic activity: | |
Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.3; Evidence={ECO:0000255|PROSITE- ProRule:PRU00660}; |
| Activity regulation: | |
Inhibited by isoniazid metabolites. The prodrug isoniazid is metabolized to isoniazid-NADP adducts that inhibit the enzyme at subnanomolar concentration. {ECO:0000269|PubMed:16648861}. |
| Pathway: | |
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8- tetrahydrofolate from 7,8-dihydrofolate: step 1/1. |
| Similarity: | |
Belongs to the dihydrofolate reductase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CCP45562.1; Type=Erroneous initiation; Note=Truncated N-terminus.; |
Annotations taken from UniProtKB at the EBI.