UniProt functional annotation for Q6AXS4



	UniProt functional annotation for Q6AXS4

UniProt code: Q6AXS4.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (v-ATPase) and the acidification of the endo-lysosomal system (By similarity). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O75787, ECO:0000250|UniProtKB:Q9CYN9}.

Subunit: Interacts with renin. Interacts with VMA21 (via N-terminus); VMA21 is a v-ATPase accessory component. Interacts with ATP6AP1 (via N- terminus). Interacts with ATP6V0D1; ATP6V0D1 is a v-ATPase complex subunit and the interaction promotes v-ATPase complex assembly. Interacts with TMEM9; TMEM9 is a v-ATPase assembly regulator and the interaction induces the interaction with ATP6V0D1. {ECO:0000250|UniProtKB:O75787}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9CYN9}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9CYN9}. Lysosome membrane {ECO:0000250|UniProtKB:Q9CYN9}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9CYN9}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q9CYN9}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CYN9}. Endosome membrane {ECO:0000250|UniProtKB:Q9CYN9}.

Ptm: Proteolytically cleaved by a furin-like convertase in the trans- Golgi network to generate N- and C-terminal fragments. {ECO:0000250|UniProtKB:O75787}.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (v-ATPase) and the acidification of the endo-lysosomal system (By similarity). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity). {ECO:0000250\|UniProtKB:O75787, ECO:0000250\|UniProtKB:Q9CYN9}.


Subunit:		Interacts with renin. Interacts with VMA21 (via N-terminus); VMA21 is a v-ATPase accessory component. Interacts with ATP6AP1 (via N- terminus). Interacts with ATP6V0D1; ATP6V0D1 is a v-ATPase complex subunit and the interaction promotes v-ATPase complex assembly. Interacts with TMEM9; TMEM9 is a v-ATPase assembly regulator and the interaction induces the interaction with ATP6V0D1. {ECO:0000250\|UniProtKB:O75787}.
Subcellular location:		Endoplasmic reticulum membrane {ECO:0000250\|UniProtKB:Q9CYN9}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q9CYN9}. Lysosome membrane {ECO:0000250\|UniProtKB:Q9CYN9}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250\|UniProtKB:Q9CYN9}. Cell projection, dendritic spine membrane {ECO:0000250\|UniProtKB:Q9CYN9}. Cell projection, axon {ECO:0000250\|UniProtKB:Q9CYN9}. Endosome membrane {ECO:0000250\|UniProtKB:Q9CYN9}.
Ptm:		Proteolytically cleaved by a furin-like convertase in the trans- Golgi network to generate N- and C-terminal fragments. {ECO:0000250\|UniProtKB:O75787}.