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UniProt functional annotation for P25286 | ||
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| UniProt code: P25286. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). {ECO:0000250}. |
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| Subunit: | |
The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''. Interacts with SPAAR. {ECO:0000250|UniProtKB:Q93050}. |
| Subcellular location: | |
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome {ECO:0000250}. Note=Coated vesicle. |
| Similarity: | |
Belongs to the V-ATPase 116 kDa subunit family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.