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UniProt functional annotation for P55915 | ||
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| UniProt code: P55915. |
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| Organism: | |
Canavalia brasiliensis (Brazilian jack bean). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade; NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Canavalia. |
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| Function: | |
Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml. {ECO:0000269|PubMed:10747944, ECO:0000269|PubMed:1398779, ECO:0000269|PubMed:18472821, ECO:0000269|PubMed:19765980, ECO:0000269|PubMed:7524287, ECO:0000269|PubMed:8891754, ECO:0000269|PubMed:9575151}. |
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| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:10506175}. |
| Toxic dose: | |
LC(50) is 15.4 ug/ml against the brine shrimp A.salina. {ECO:0000269|PubMed:19765980}. |
| Miscellaneous: | |
Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide- binding and cell-agglutinating activities. |
| Miscellaneous: | |
Is being tested as a molluscicide with potential application in controlling schistosomiasis. The causative agent of schistosomiasis depends on freshwater snails of the genus Biomphalaria as hosts during its larval stages. |
| Similarity: | |
Belongs to the leguminous lectin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.