UniProt functional annotation for P08172



	UniProt functional annotation for P08172

UniProt code: P08172.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}.

Subunit: Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization. {ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:7822302}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}; Multi-pass membrane protein {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250|UniProtKB:P06199}.

Induction: Up-regulated in response to enterovirus 71 (EV71) infection. {ECO:0000269|PubMed:16548883}.

Ptm: Phosphorylated in response to agonist treatment. {ECO:0000250}.

Polymorphism: Genetic variations in CHRM2 can influence susceptibility to alcoholism [MIM:103780]. {ECO:0000305|PubMed:15229186}.

Disease: Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. {ECO:0000269|PubMed:15229186}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Similarity: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269\|PubMed:24256733, ECO:0000269\|PubMed:3443095}.


Subunit:		Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization. {ECO:0000269\|PubMed:20976005, ECO:0000269\|PubMed:22278061, ECO:0000269\|PubMed:7822302}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:22278061, ECO:0000269\|PubMed:24256733, ECO:0000269\|PubMed:3443095}; Multi-pass membrane protein {ECO:0000269\|PubMed:22278061, ECO:0000269\|PubMed:24256733}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250\|UniProtKB:P06199}.
Induction:		Up-regulated in response to enterovirus 71 (EV71) infection. {ECO:0000269\|PubMed:16548883}.
Ptm:		Phosphorylated in response to agonist treatment. {ECO:0000250}.
Polymorphism:		Genetic variations in CHRM2 can influence susceptibility to alcoholism [MIM:103780]. {ECO:0000305\|PubMed:15229186}.
Disease:		Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. {ECO:0000269\|PubMed:15229186}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
Similarity:		Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00521}.