UniProt functional annotation for Q94CL7



	UniProt functional annotation for Q94CL7

UniProt code: Q94CL7.

Organism: Arabidopsis thaliana (Mouse-ear cress).

Taxonomy: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.

Function: Transcription factor involved in phosphate starvation signaling (PubMed:11511543, PubMed:17927693, PubMed:26586833). Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation- responsive genes (PubMed:11511543, PubMed:20838596, PubMed:26586833). SPX1 is a competitive inhibitor of this DNA-binding (PubMed:25271326). PHR1 binding to its targets is low Pi-dependent (PubMed:25271326). Regulates the expression of miR399 (PubMed:20838596). Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions (PubMed:17643101). Regulates lipid remodeling and triacylglycerol accumulation during phosphorus starvation (PubMed:25680792). Required for the shoot-specific hypoxic response (PubMed:24753539). Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis (PubMed:23788639). Contributes to the homeostasis of both sulfate and phosphate in plants under phosphate deficiency (PubMed:21261953). Required for adaptation to high light and retaining functional photosynthesis during phosphate starvation (PubMed:21910737). Involved in the coregulation of Zn and Pi homeostasis (PubMed:24420568). {ECO:0000269|PubMed:11511543, ECO:0000269|PubMed:17643101, ECO:0000269|PubMed:17927693, ECO:0000269|PubMed:20838596, ECO:0000269|PubMed:21261953, ECO:0000269|PubMed:21910737, ECO:0000269|PubMed:23788639, ECO:0000269|PubMed:24420568, ECO:0000269|PubMed:24753539, ECO:0000269|PubMed:25271326, ECO:0000269|PubMed:25680792, ECO:0000269|PubMed:26586833}.

Subunit: Homodimers and heterodimers (PubMed:20838596, PubMed:11511543). Interacts with SPX1 in a Pi-dependent manner (PubMed:25271326). Does not interact with PHL2 or PHL3 (PubMed:26586833). {ECO:0000269|PubMed:11511543, ECO:0000269|PubMed:25271326, ECO:0000269|PubMed:26586833}.

Subcellular location: Nucleus {ECO:0000269|PubMed:11511543}. Note=The localization to the nucleus is independent of the Pi status. {ECO:0000269|PubMed:11511543}.

Induction: Only moderately up-regulated by Pi starvation. {ECO:0000269|PubMed:11511543}.

Ptm: Sumoylated by SIZ1. Sumoylation controls phosphate deficiency responses. {ECO:0000269|PubMed:15894620}.

Disruption phenotype: Strongly reduced shoot growth, and slightly increased root growth. Reduced expression of phosphate starvation- induced (PSI) genes, decreased cellular inorganic phosphate (Pi) content and shoot-to-root ratio, and impaired anthocyanin accumulation (PubMed:17927693). {ECO:0000269|PubMed:17927693}.

Similarity: Belongs to the MYB-CC family. {ECO:0000305}.

Sequence caution: Sequence=CAB81449.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Arabidopsis thaliana (Mouse-ear cress).
Taxonomy:		Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.



Function:		Transcription factor involved in phosphate starvation signaling (PubMed:11511543, PubMed:17927693, PubMed:26586833). Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation- responsive genes (PubMed:11511543, PubMed:20838596, PubMed:26586833). SPX1 is a competitive inhibitor of this DNA-binding (PubMed:25271326). PHR1 binding to its targets is low Pi-dependent (PubMed:25271326). Regulates the expression of miR399 (PubMed:20838596). Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions (PubMed:17643101). Regulates lipid remodeling and triacylglycerol accumulation during phosphorus starvation (PubMed:25680792). Required for the shoot-specific hypoxic response (PubMed:24753539). Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis (PubMed:23788639). Contributes to the homeostasis of both sulfate and phosphate in plants under phosphate deficiency (PubMed:21261953). Required for adaptation to high light and retaining functional photosynthesis during phosphate starvation (PubMed:21910737). Involved in the coregulation of Zn and Pi homeostasis (PubMed:24420568). {ECO:0000269\|PubMed:11511543, ECO:0000269\|PubMed:17643101, ECO:0000269\|PubMed:17927693, ECO:0000269\|PubMed:20838596, ECO:0000269\|PubMed:21261953, ECO:0000269\|PubMed:21910737, ECO:0000269\|PubMed:23788639, ECO:0000269\|PubMed:24420568, ECO:0000269\|PubMed:24753539, ECO:0000269\|PubMed:25271326, ECO:0000269\|PubMed:25680792, ECO:0000269\|PubMed:26586833}.


Subunit:		Homodimers and heterodimers (PubMed:20838596, PubMed:11511543). Interacts with SPX1 in a Pi-dependent manner (PubMed:25271326). Does not interact with PHL2 or PHL3 (PubMed:26586833). {ECO:0000269\|PubMed:11511543, ECO:0000269\|PubMed:25271326, ECO:0000269\|PubMed:26586833}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:11511543}. Note=The localization to the nucleus is independent of the Pi status. {ECO:0000269\|PubMed:11511543}.
Induction:		Only moderately up-regulated by Pi starvation. {ECO:0000269\|PubMed:11511543}.
Ptm:		Sumoylated by SIZ1. Sumoylation controls phosphate deficiency responses. {ECO:0000269\|PubMed:15894620}.
Disruption phenotype:		Strongly reduced shoot growth, and slightly increased root growth. Reduced expression of phosphate starvation- induced (PSI) genes, decreased cellular inorganic phosphate (Pi) content and shoot-to-root ratio, and impaired anthocyanin accumulation (PubMed:17927693). {ECO:0000269\|PubMed:17927693}.
Similarity:		Belongs to the MYB-CC family. {ECO:0000305}.
Sequence caution:		Sequence=CAB81449.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};