UniProt functional annotation for P37299



	UniProt functional annotation for P37299

UniProt code: P37299.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). QCR10 has a role in CIII assembly and RIP1 stability (PubMed:8175712, PubMed:30598556, PubMed:30598554). {ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556, ECO:0000269|PubMed:8175712, ECO:0000305|PubMed:30598554}.

Subunit: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554). QCR10 interacts with CYT1, QCR9 and RIP1 on the intermembrane space (IMS) and with COR2 and QCR7 on the matrix side (PubMed:30598556, PubMed:30598554). {ECO:0000269|PubMed:10764779, ECO:0000269|PubMed:10775262, ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:30598554}; Single-pass membrane protein {ECO:0000269|PubMed:30598554}.

Miscellaneous: Present with 5590 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Similarity: Belongs to the UQCR11/QCR10 family. {ECO:0000305}.

Sequence caution: Sequence=AAB68434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). QCR10 has a role in CIII assembly and RIP1 stability (PubMed:8175712, PubMed:30598556, PubMed:30598554). {ECO:0000269\|PubMed:30598554, ECO:0000269\|PubMed:30598556, ECO:0000269\|PubMed:8175712, ECO:0000305\|PubMed:30598554}.


Subunit:		Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554). QCR10 interacts with CYT1, QCR9 and RIP1 on the intermembrane space (IMS) and with COR2 and QCR7 on the matrix side (PubMed:30598556, PubMed:30598554). {ECO:0000269\|PubMed:10764779, ECO:0000269\|PubMed:10775262, ECO:0000269\|PubMed:30598554, ECO:0000269\|PubMed:30598556}.
Subcellular location:		Mitochondrion inner membrane {ECO:0000269\|PubMed:30598554}; Single-pass membrane protein {ECO:0000269\|PubMed:30598554}.
Miscellaneous:		Present with 5590 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity:		Belongs to the UQCR11/QCR10 family. {ECO:0000305}.
Sequence caution:		Sequence=AAB68434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};