UniProt functional annotation for P31947



	UniProt functional annotation for P31947

UniProt code: P31947.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269|PubMed:18382127}.

Function: p53-regulated inhibitor of G2/M progression. {ECO:0000269|PubMed:18382127}.

Subunit: Homodimer (PubMed:28202711). Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with COP1; this interaction leads to proteasomal degradation. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711). {ECO:0000250, ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15282546, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:19172738, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:19640509, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:23572552, ECO:0000269|PubMed:26047703, ECO:0000269|PubMed:28202711}.

Subcellular location: Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.

Tissue specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Ptm: Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. {ECO:0000269|PubMed:18382127}.

Similarity: Belongs to the 14-3-3 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269\|PubMed:18382127}.



Function:		p53-regulated inhibitor of G2/M progression. {ECO:0000269\|PubMed:18382127}.


Subunit:		Homodimer (PubMed:28202711). Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with COP1; this interaction leads to proteasomal degradation. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711). {ECO:0000250, ECO:0000250\|UniProtKB:O70456, ECO:0000269\|PubMed:15282546, ECO:0000269\|PubMed:15731107, ECO:0000269\|PubMed:19172738, ECO:0000269\|PubMed:19592491, ECO:0000269\|PubMed:19640509, ECO:0000269\|PubMed:21625211, ECO:0000269\|PubMed:22634725, ECO:0000269\|PubMed:23572552, ECO:0000269\|PubMed:26047703, ECO:0000269\|PubMed:28202711}.
Subcellular location:		Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
Tissue specificity:		Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Ptm:		Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. {ECO:0000269\|PubMed:18382127}.
Similarity:		Belongs to the 14-3-3 family. {ECO:0000305}.