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UniProt functional annotation for P49735 | ||
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| UniProt code: P49735. |
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| Organism: | |
Drosophila melanogaster (Fruit fly). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
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| Function: | |
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. {ECO:0000269|PubMed:16798881, ECO:0000269|PubMed:20122406, ECO:0000269|PubMed:7622035}. |
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| Catalytic activity: | |
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; |
| Subunit: | |
Component of the Mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order Mcm2-Mcm6-Mcm4-Mcm7- Mcm3-Mcm5 (Probable). Interacts with Mcm10. {ECO:0000269|PubMed:11854416, ECO:0000269|PubMed:12808023, ECO:0000269|PubMed:16798881, ECO:0000305}. |
| Subcellular location: | |
Nucleus {ECO:0000305}. |
| Similarity: | |
Belongs to the MCM family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.