 |
PDBsum entry 6pvq
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Transport protein
|
PDB id
|
|
|
|
6pvq
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
Structural basis of temperature sensation by the trp channel trpv3.
|
|
|
Authors
|
|
A.K.Singh,
L.L.Mcgoldrick,
L.Demirkhanyan,
M.Leslie,
E.Zakharian,
A.I.Sobolevsky.
|
|
|
Ref.
|
|
Nat Struct Mol Biol, 2019,
26,
994-998.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
We present structures of mouse TRPV3 in temperature-dependent open, closed and
intermediate states that suggest two-step activation of TRPV3 by heat. During
the strongly temperature-dependent first step, sensitization, the channel pore
remains closed while S6 helices undergo α-to-π transitions. During the weakly
temperature-dependent second step, channel opening, tight association of the
S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and
linker domains.
|
|
|
|
|
|
|
