|
|
||
|
|
|
|
|
UniProt functional annotation for J1IY24 | ||
|
|
|
|
|
|
||
| UniProt code: J1IY24. |
|
||
| Organism: | |
Bartonella birtlesii LL-WM9. |
| Taxonomy: | |
Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bartonellaceae; Bartonella. |
|
||
|
||
| Function: | |
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication. {ECO:0000256|PIRNR:PIRNR000804}. |
|
||
| Subunit: | |
Forms a ring-shaped head-to-tail homodimer around DNA. {ECO:0000256|PIRNR:PIRNR000804}. |
| Subcellular location: | |
Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR000804}. |
| Similarity: | |
Belongs to the beta sliding clamp family. {ECO:0000256|ARBA:ARBA00010752, ECO:0000256|PIRNR:PIRNR000804}. |
Annotations taken from UniProtKB at the EBI.