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PDBsum entry 6prm
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References listed in PDB file
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Key reference
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Title
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Insights into the κ/ι-Carrageenan metabolism pathway of some marine pseudoalteromonas species.
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Authors
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A.G.Hettle,
J.K.Hobbs,
B.Pluvinage,
C.Vickers,
K.T.Abe,
O.Salama-Alber,
B.E.Mcguire,
J.H.Hehemann,
J.P.M.Hui,
F.Berrue,
A.Banskota,
J.Zhang,
E.M.Bottos,
J.Van hamme,
A.B.Boraston.
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Ref.
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Commun Biol, 2019,
2,
474.
[DOI no: ]
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PubMed id
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Note: In the PDB file this reference is
annotated as "TO BE PUBLISHED". The citation details given above have
been manually determined.
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Abstract
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Pseudoalteromonas is a globally distributed marine-associated genus that
can be found in a broad range of aquatic environments, including in association
with macroalgal surfaces where they may take advantage of these rich sources of
polysaccharides. The metabolic systems that confer the ability to metabolize
this abundant form of photosynthetically fixed carbon, however, are not yet
fully understood. Through genomics, transcriptomics, microbiology, and specific
structure-function studies of pathway components we address the capacity of
newly isolated marine pseudoalteromonads to metabolize the red algal galactan
carrageenan. The results reveal that the κ/ι-carrageenan specific
polysaccharide utilization locus (CarPUL) enables isolates possessing this locus
the ability to grow on this substrate. Biochemical and structural analysis of
the enzymatic components of the CarPUL promoted the development of a detailed
model of the κ/ι-carrageenan metabolic pathway deployed by pseudoalteromonads,
thus furthering our understanding of how these microbes have adapted to a unique
environmental niche.
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