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UniProt functional annotation for P25924 | ||
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| UniProt code: P25924. |
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| Organism: | |
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella. |
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| Function: | |
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. {ECO:0000269|PubMed:14595395}. |
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| Catalytic activity: | |
Reaction=2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:32459, ChEBI:CHEBI:15378, ChEBI:CHEBI:57308, ChEBI:CHEBI:57856, ChEBI:CHEBI:58827, ChEBI:CHEBI:59789; EC=2.1.1.107; Evidence={ECO:0000269|PubMed:14595395}; |
| Catalytic activity: | |
Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin; Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76; Evidence={ECO:0000269|PubMed:14595395}; |
| Catalytic activity: | |
Reaction=2 H(+) + siroheme = Fe(2+) + sirohydrochlorin; Xref=Rhea:RHEA:24360, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:58351, ChEBI:CHEBI:60052; EC=4.99.1.4; Evidence={ECO:0000269|PubMed:14595395}; |
| Pathway: | |
Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1. {ECO:0000255|HAMAP- Rule:MF_01646}. |
| Pathway: | |
Cofactor biosynthesis; adenosylcobalamin biosynthesis; sirohydrochlorin from precorrin-2: step 1/1. {ECO:0000255|HAMAP- Rule:MF_01646}. |
| Pathway: | |
Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01646}. |
| Pathway: | |
Porphyrin-containing compound metabolism; siroheme biosynthesis; siroheme from sirohydrochlorin: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01646}. |
| Pathway: | |
Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01646}. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:14595395}. |
| Similarity: | |
In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. {ECO:0000255|HAMAP-Rule:MF_01646}. |
| Similarity: | |
In the C-terminal section; belongs to the precorrin methyltransferase family. {ECO:0000255|HAMAP-Rule:MF_01646}. |
Annotations taken from UniProtKB at the EBI.