UniProt functional annotation for Q9H7Z6



	UniProt functional annotation for Q9H7Z6

UniProt code: Q9H7Z6.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126). May influence the function of ATM (PubMed:15923642). As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026). That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026). Can also acetylate TP53/p53 at 'Lys-120'. {ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:15923642, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026}.

Catalytic activity: Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000269|PubMed:10786633, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000305|PubMed:16543150};

Subunit: Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1 (PubMed:16227571, PubMed:16543150). Interacts with MSL1; the interaction is direct (PubMed:21217699, PubMed:22547026). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:16543150, PubMed:20018852). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Interacts with the chromodomain of MORF4L1/MRG15 (PubMed:12397079). Interacts with ATM through the chromodomain (PubMed:15923642). Interacts with KANSL1; the interaction is direct (PubMed:16543150, PubMed:20620954, PubMed:21217699, PubMed:22547026). Interacts with MSL3 (PubMed:21217699, PubMed:22547026, PubMed:30224647). Interacts with NELFD (By similarity). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:15923642, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20620954, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:21691301, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30224647}.

Subcellular location: Nucleus {ECO:0000269|PubMed:10786633, ECO:0000269|PubMed:20018852}. Chromosome {ECO:0000250}.

Ptm: Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function. {ECO:0000269|PubMed:22020126}.

Similarity: Belongs to the MYST (SAS/MOZ) family. {ECO:0000305}.

Sequence caution: Sequence=AAL55762.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAL56648.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126). May influence the function of ATM (PubMed:15923642). As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026). That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026). Can also acetylate TP53/p53 at 'Lys-120'. {ECO:0000269\|PubMed:12397079, ECO:0000269\|PubMed:15923642, ECO:0000269\|PubMed:16227571, ECO:0000269\|PubMed:16543150, ECO:0000269\|PubMed:20018852, ECO:0000269\|PubMed:21217699, ECO:0000269\|PubMed:22020126, ECO:0000269\|PubMed:22547026}.


Catalytic activity:		Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000269\|PubMed:10786633, ECO:0000269\|PubMed:21217699, ECO:0000269\|PubMed:22020126, ECO:0000269\|PubMed:22547026, ECO:0000305\|PubMed:16543150};
Subunit:		Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1 (PubMed:16227571, PubMed:16543150). Interacts with MSL1; the interaction is direct (PubMed:21217699, PubMed:22547026). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:16543150, PubMed:20018852). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Interacts with the chromodomain of MORF4L1/MRG15 (PubMed:12397079). Interacts with ATM through the chromodomain (PubMed:15923642). Interacts with KANSL1; the interaction is direct (PubMed:16543150, PubMed:20620954, PubMed:21217699, PubMed:22547026). Interacts with MSL3 (PubMed:21217699, PubMed:22547026, PubMed:30224647). Interacts with NELFD (By similarity). {ECO:0000250\|UniProtKB:Q9D1P2, ECO:0000269\|PubMed:12397079, ECO:0000269\|PubMed:15923642, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:16227571, ECO:0000269\|PubMed:16543150, ECO:0000269\|PubMed:20018852, ECO:0000269\|PubMed:20620954, ECO:0000269\|PubMed:21217699, ECO:0000269\|PubMed:21691301, ECO:0000269\|PubMed:22547026, ECO:0000269\|PubMed:30224647}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:10786633, ECO:0000269\|PubMed:20018852}. Chromosome {ECO:0000250}.
Ptm:		Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function. {ECO:0000269\|PubMed:22020126}.
Similarity:		Belongs to the MYST (SAS/MOZ) family. {ECO:0000305}.
Sequence caution:		Sequence=AAL55762.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAL56648.1; Type=Frameshift; Evidence={ECO:0000305};