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UniProt functional annotation for Q13324 | ||
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| UniProt code: Q13324. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. |
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| Subunit: | |
Monomer. Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3. {ECO:0000269|PubMed:20966082, ECO:0000269|PubMed:22689579}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:22689579}; Multi-pass membrane protein {ECO:0000269|PubMed:22689579}. |
| Domain: | |
The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity). {ECO:0000250}. |
| Domain: | |
The uncleaved pseudo signal peptide prevents receptor's oligomerization and coupling to G(i) subunits. It is also responsible for the rather low receptor localization at the plasma membrane (PubMed:22689579). {ECO:0000269|PubMed:22689579}. |
| Ptm: | |
A N-glycosylation site within the signal peptide impedes its proper cleavage and function. {ECO:0000250}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.