UniProt functional annotation for G1TLT8



	UniProt functional annotation for G1TLT8

UniProt code: G1TLT8.

Organism: Oryctolagus cuniculus (Rabbit).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.

Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000256|HAMAP-Rule:MF_03016}.

Subunit: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B. {ECO:0000256|HAMAP-Rule:MF_03016}.

Subcellular location: Cell membrane {ECO:0000256|HAMAP-Rule:MF_03016}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|HAMAP- Rule:MF_03016}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co- localizes with PPP1R16B in the cell membrane. {ECO:0000256|HAMAP- Rule:MF_03016}.

Ptm: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. {ECO:0000256|HAMAP-Rule:MF_03016}.

Ptm: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. {ECO:0000256|HAMAP-Rule:MF_03016}.

Miscellaneous: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. {ECO:0000256|HAMAP-Rule:MF_03016}.

Similarity: Belongs to the universal ribosomal protein uS2 family. {ECO:0000256|ARBA:ARBA00006242, ECO:0000256|HAMAP-Rule:MF_03016, ECO:0000256|RuleBase:RU003631}.

Annotations taken from UniProtKB at the EBI.


Organism:		Oryctolagus cuniculus (Rabbit).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.



Function:		Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000256\|HAMAP-Rule:MF_03016}.


Subunit:		Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B. {ECO:0000256\|HAMAP-Rule:MF_03016}.
Subcellular location:		Cell membrane {ECO:0000256\|HAMAP-Rule:MF_03016}. Cytoplasm {ECO:0000256\|ARBA:ARBA00004496, ECO:0000256\|HAMAP- Rule:MF_03016}. Nucleus {ECO:0000256\|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co- localizes with PPP1R16B in the cell membrane. {ECO:0000256\|HAMAP- Rule:MF_03016}.
Ptm:		Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. {ECO:0000256\|HAMAP-Rule:MF_03016}.
Ptm:		Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. {ECO:0000256\|HAMAP-Rule:MF_03016}.
Miscellaneous:		This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. {ECO:0000256\|HAMAP-Rule:MF_03016}.
Similarity:		Belongs to the universal ribosomal protein uS2 family. {ECO:0000256\|ARBA:ARBA00006242, ECO:0000256\|HAMAP-Rule:MF_03016, ECO:0000256\|RuleBase:RU003631}.