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UniProt functional annotation for P56726 | ||
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| UniProt code: P56726. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO) (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602). {ECO:0000250|UniProtKB:Q99835, ECO:0000269|PubMed:25644602}. |
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| Subunit: | |
Homodimer (By similarity). Interacts with ARRB2 (PubMed:15618519). Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO (PubMed:22072986). Interacts with KIF7, DLG5 and SDCBP (PubMed:25644602). Interacts with GAS8/DRC4 (PubMed:21659505). {ECO:0000250|UniProtKB:Q99835, ECO:0000269|PubMed:15618519, ECO:0000269|PubMed:21659505, ECO:0000269|PubMed:22072986, ECO:0000269|PubMed:25644602}. |
| Subcellular location: | |
Membrane; Multi-pass membrane protein. Cell projection, cilium {ECO:0000269|PubMed:21659505, ECO:0000269|PubMed:25644602}. |
| Similarity: | |
Belongs to the G-protein coupled receptor Fz/Smo family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.