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UniProt functional annotation for P0DJI8 | ||
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| UniProt code: P0DJI8. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Major acute phase protein. |
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| Subunit: | |
Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin. {ECO:0000269|PubMed:24706838, ECO:0000269|PubMed:7115671}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:7115671}. |
| Tissue specificity: | |
Expressed by the liver; secreted in plasma (at protein level). {ECO:0000269|PubMed:12973732, ECO:0000269|PubMed:4816450, ECO:0000269|PubMed:7115671}. |
| Induction: | |
Upon cytokine stimulation. |
| Ptm: | |
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end. |
| Mass spectrometry: | |
[Serum amyloid A-1 protein]: Mass=11702; Mass_error=14; Method=MALDI; Evidence={ECO:0000269|PubMed:12973732}; |
| Mass spectrometry: | |
[Serum amyloid A-1 protein]: Mass=11682.7; Method=MALDI; Evidence={ECO:0000269|PubMed:12606051}; |
| Mass spectrometry: | |
[Serum amyloid protein A(2-104)]: Mass=11526.5; Method=MALDI; Evidence={ECO:0000269|PubMed:12606051}; |
| Mass spectrometry: | |
[Serum amyloid protein A(3-104)]: Mass=11439.6; Method=MALDI; Evidence={ECO:0000269|PubMed:12606051}; |
| Mass spectrometry: | |
[Serum amyloid protein A(2-103)]: Mass=11363.6; Method=MALDI; Evidence={ECO:0000269|PubMed:12606051}; |
| Mass spectrometry: | |
[Serum amyloid protein A(2-102)]: Mass=11235.6; Method=MALDI; Evidence={ECO:0000269|PubMed:12606051}; |
| Mass spectrometry: | |
[Serum amyloid protein A(4-101)]: Mass=10872.6; Method=MALDI; Evidence={ECO:0000269|PubMed:12606051}; |
| Mass spectrometry: | |
[Amyloid protein A]: Mass=8337.5; Mass_error=0.8; Method=Electrospray; Note=With variants Ala-70, Val-75, Asn-78 and 86- Leu-Thr-87.; Evidence={ECO:0000269|PubMed:1463770}; |
| Mass spectrometry: | |
[Amyloid protein A]: Mass=8390.9; Mass_error=0.2; Method=Electrospray; Note=With variant Ala-70.; Evidence={ECO:0000269|PubMed:1463770}; |
| Polymorphism: | |
At least 5 different SAA1 alleles have been described: SAA1.1 (SAA1alpha), SAA1.2 (SAA1beta), SAA1.3 (SAA1gamma), SAA1.4 (SAA1delta), SAA1.5 (also named SAA1beta but which differs from SAA1.2). We use here the revised nomenclature described in PubMed:10211414. The sequence shown is that of SAA1.1. |
| Disease: | |
Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. {ECO:0000269|PubMed:1463770}. |
| Disease: | |
Note=Elevated serum SAA1 protein levels may be associated with lung cancer. {ECO:0000269|PubMed:1463770}. |
| Similarity: | |
Belongs to the SAA family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.