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UniProt functional annotation for P18825 | ||
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| UniProt code: P18825. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. |
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| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. |
| Polymorphism: | |
The Del322-325 variant has a significant loss of function. It is approximately 10 times more frequent in African- Americans compared with Caucasians (allele frequencies 0.381 versus 0.040). {ECO:0000269|PubMed:10801795}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
| Sequence caution: | |
Sequence=AAA35513.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAC78723.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.