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PDBsum entry 6jcs
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References listed in PDB file
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Key reference
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Title
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Divergent engagements between adeno-Associated viruses with their cellular receptor aavr.
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Authors
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R.Zhang,
G.Xu,
L.Cao,
Z.Sun,
Y.He,
M.Cui,
Y.Sun,
S.Li,
H.Li,
L.Qin,
M.Hu,
Z.Yuan,
Z.Rao,
W.Ding,
Z.Rao,
Z.Lou.
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Ref.
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Nat Commun, 2019,
10,
3760.
[DOI no: ]
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PubMed id
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Abstract
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Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the
entry of multiple AAV serotypes with divergent rules; however, the mechanism
remains unclear. Here, we determine the structures of the AAV1-AAVR and
AAV5-AAVR complexes, revealing the molecular details by which PKD1 recognizes
AAV5 and PKD2 is solely engaged with AAV1. PKD2 lies on the plateau region of
the AAV1 capsid. However, the AAV5-AAVR interface is strikingly different, in
which PKD1 is bound at the opposite side of the spike of the AAV5 capsid than
the PKD2-interacting region of AAV1. Residues in strands F/G and the CD loop of
PKD1 interact directly with AAV5, whereas residues in strands B/C/E and the BC
loop of PKD2 make contact with AAV1. These findings further the understanding of
the distinct mechanisms by which AAVR recognizes various AAV serotypes and
provide an example of a single receptor engaging multiple viral serotypes with
divergent rules.
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