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UniProt functional annotation for P28004 | ||
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| UniProt code: P28004. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Involved in pre-mRNA splicing. Associated with the spliceosome throughout the splicing reactions, until after the second catalytic step. {ECO:0000269|PubMed:12359070, ECO:0000269|PubMed:12554883}. |
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| Subunit: | |
Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with CLF1, PRP22 and PRP46. Interacts with SPP382. {ECO:0000269|PubMed:11884590, ECO:0000269|PubMed:12554883, ECO:0000269|PubMed:14690591}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:12359070, ECO:0000269|PubMed:14562095}. |
| Miscellaneous: | |
Present with 1670 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the SNW family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAA44455.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.