 |
PDBsum entry 6j2f
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Immune system
|
PDB id
|
|
|
|
6j2f
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
Peptide presentation by bat mhc class i provides new insight into the antiviral immunity of bats.
|
|
|
Authors
|
|
D.Lu,
K.Liu,
D.Zhang,
C.Yue,
Q.Lu,
H.Cheng,
L.Wang,
Y.Chai,
J.Qi,
L.F.Wang,
G.F.Gao,
W.J.Liu.
|
|
|
Ref.
|
|
PLoS Biol, 2019,
17,
e3000436.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans
and other mammals, but they are typically asymptomatic in bats. To further
understand the antiviral immunity of bats, we screened and identified a series
of bat major histocompatibility complex (MHC) I Ptal-N*01:01-binding peptides
derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola
virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and
H17N10 influenza-like virus. The structures of Ptal-N*01:01 display unusual
peptide presentation features in that the bat-specific 3-amino acid (aa)
insertion enables the tight "surface anchoring" of the P1-Asp in
pocket A of bat MHC I. As the classical primary anchoring positions, the B and F
pockets of Ptal-N*01:01 also show unconventional conformations, which contribute
to unusual peptide motifs and distinct peptide presentation. Notably, the
features of bat MHC I may be shared by MHC I from various marsupials. Our study
sheds light on bat adaptive immunity and may benefit future vaccine development
against bat-borne viruses of high impact on humans.
|
|
|
|
|
|
|
