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PDBsum entry 6itx
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Cell adhesion
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PDB id
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6itx
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References listed in PDB file
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Key reference
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Title
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Unravelling the receptor binding property of egg drop syndrome virus (edsv) from the crystal structure of edsv fiber head.
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Authors
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Y.Song,
Q.Wei,
Y.Liu,
H.Feng,
Y.Chen,
Y.Wang,
Y.Bai,
G.Xing,
R.Deng,
G.Zhang.
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Ref.
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Int J Biol Macromol, 2019,
139,
587-595.
[DOI no: ]
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PubMed id
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Abstract
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Egg drop syndrome virus (EDSV) is an avian adenovirus that causes markedly
decrease in egg production, and in the quality of the eggs when it infects
chickens. Until now, EDSV virus-cell interactions are poorly understood, and the
cellular receptor is still unknown. In the present study, we determined the
atomic structure of the fiber head of EDSV (residues 377-644) at 2.74 Å
resolution. Structure comparison with the (chick embryo lethal orphan) CELO long
fiber head and human adenovirus fiber heads reveals that the avian adenovirus
may interact with the same attachment factor in a unique fashion. Based on the
previous studies of CELO virus, we assumed that the chicken coxsackievirus and
adenovirus receptor (CAR) may be the attachment factor. We then demonstrate that
the chicken CAR serves as a cellular attachment factor for EDSV based on three
lines of evidences. Taken together, the results presented here are helpful for
further exploring the pathogenesis related to the interaction between EDSV and
host cells, and may be used for vaccine development and intervention strategies
against EDSV infection.
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