|
|
||
|
|
|
|
|
UniProt functional annotation for P41223 | ||
|
|
|
|
|
|
||
| UniProt code: P41223. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Involved in the pre-mRNA splicing process (PubMed:28502770, PubMed:28076346). May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity (PubMed:25091737). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:25091737}. |
|
||
| Subunit: | |
Identified in the spliceosome C complex (PubMed:28502770, PubMed:28076346). May interact with AR (PubMed:25091737). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:25091737}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:25091737, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. Note=Detected in chromatin at the promoter of AR target genes. {ECO:0000305|PubMed:25091737}. |
| Tissue specificity: | |
Detected in epithelial and stromal cells in benign prostate hyperplasia tissue (at protein level). {ECO:0000269|PubMed:25091737}. |
| Domain: | |
Contains a short sequence motif (Phe-Xaa-Xaa-Phe-Tyr) that can bind to AR and may modulate AR activity. {ECO:0000305|PubMed:25091737}. |
| Similarity: | |
Belongs to the BUD31 (G10) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.