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UniProt functional annotation for P24768 | ||
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| UniProt code: P24768. |
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| Organism: | |
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)). |
| Taxonomy: | |
Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes; Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus. |
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| Function: | |
Probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins. |
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| Subunit: | |
Interacts (via BTB domain) with host CUL3. {ECO:0000250}. |
| Subcellular location: | |
Host cytoplasm {ECO:0000250}. |
| Domain: | |
The BTB domain is responsible for the interaction with CUL3 while the Kelch repeat domains supposely serve to recruit the cellular substrates. {ECO:0000250}. |
| Similarity: | |
Belongs to the poxviruses A55 protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.