UniProt functional annotation for P40306



	UniProt functional annotation for P40306

UniProt code: P40306.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

Catalytic activity: Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1;

Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. {ECO:0000269|PubMed:14550573}.

Subunit: (Microbial infection) Interacts with HIV-1 TAT protein. {ECO:0000269|PubMed:14550573}.

Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.

Developmental stage: Highly expressed in immature dendritic cells (at protein level). {ECO:0000269|PubMed:11717192}.

Induction: Up-regulated by IFNG/IFN-gamma (at protein level). Up- regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells. {ECO:0000269|PubMed:10575004, ECO:0000269|PubMed:11493458, ECO:0000269|PubMed:15501285, ECO:0000269|PubMed:15907481, ECO:0000269|PubMed:17262812, ECO:0000269|PubMed:18694960, ECO:0000269|PubMed:8666937}.

Ptm: Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity. {ECO:0000250|UniProtKB:O35955}.

Similarity: Belongs to the peptidase T1B family. {ECO:0000255|PROSITE- ProRule:PRU00809}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.


Catalytic activity:		Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1;
Subunit:		The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. {ECO:0000269\|PubMed:14550573}.
Subunit:		(Microbial infection) Interacts with HIV-1 TAT protein. {ECO:0000269\|PubMed:14550573}.
Subcellular location:		Cytoplasm {ECO:0000255\|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
Developmental stage:		Highly expressed in immature dendritic cells (at protein level). {ECO:0000269\|PubMed:11717192}.
Induction:		Up-regulated by IFNG/IFN-gamma (at protein level). Up- regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells. {ECO:0000269\|PubMed:10575004, ECO:0000269\|PubMed:11493458, ECO:0000269\|PubMed:15501285, ECO:0000269\|PubMed:15907481, ECO:0000269\|PubMed:17262812, ECO:0000269\|PubMed:18694960, ECO:0000269\|PubMed:8666937}.
Ptm:		Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity. {ECO:0000250\|UniProtKB:O35955}.
Similarity:		Belongs to the peptidase T1B family. {ECO:0000255\|PROSITE- ProRule:PRU00809}.