UniProt functional annotation for Q9H9F9



	UniProt functional annotation for Q9H9F9

UniProt code: Q9H9F9.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. {ECO:0000269|PubMed:19014934, ECO:0000269|PubMed:20855601}.

Subunit: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP- binding and the helicase C-terminal domain of INO80. Interacts with DDB1. Interacts with ACTR8; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells. {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:18163988, ECO:0000269|PubMed:18922472, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}.

Subcellular location: Nucleus {ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:18163988, ECO:0000269|PubMed:19014934}. Cytoplasm {ECO:0000269|PubMed:19014934}. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling (PubMed:19014934). Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses (PubMed:18163988).

Similarity: Belongs to the actin family. ARP5 subfamily. {ECO:0000305}.

Sequence caution: Sequence=AAO65164.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. {ECO:0000269\|PubMed:19014934, ECO:0000269\|PubMed:20855601}.


Subunit:		Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP- binding and the helicase C-terminal domain of INO80. Interacts with DDB1. Interacts with ACTR8; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells. {ECO:0000269\|PubMed:16230350, ECO:0000269\|PubMed:18163988, ECO:0000269\|PubMed:18922472, ECO:0000269\|PubMed:20855601, ECO:0000269\|PubMed:21303910}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:18026119, ECO:0000269\|PubMed:18163988, ECO:0000269\|PubMed:19014934}. Cytoplasm {ECO:0000269\|PubMed:19014934}. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling (PubMed:19014934). Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses (PubMed:18163988).
Similarity:		Belongs to the actin family. ARP5 subfamily. {ECO:0000305}.
Sequence caution:		Sequence=AAO65164.1; Type=Frameshift; Evidence={ECO:0000305};