|
|
||
|
|
|
|
|
UniProt functional annotation for P54830 | ||
|
|
|
|
|
|
||
| UniProt code: P54830. |
|
||
| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
|
||
|
||
| Function: | |
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. {ECO:0000250}. |
|
||
| Catalytic activity: | |
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE- ProRule:PRU10044}; |
| Subcellular location: | |
[Isoform STEP61]: Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Subcellular location: | |
[Isoform STEP46]: Cytoplasm. |
| Tissue specificity: | |
STEP20 is expressed only in the CNS. |
| Ptm: | |
Phosphorylation at Ser-221 by PKA deactivates PTPN5. Phosphorylation at Thr-231 and Ser-244 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin- mediated degradation of the active phosphatase (By similarity). {ECO:0000250}. |
| Miscellaneous: | |
[Isoform STEP38]: Lacks the catalytic domain. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform STEP20]: Lacks the catalytic domain. {ECO:0000305}. |
| Similarity: | |
Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.