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UniProt functional annotation for O14618 | ||
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| UniProt code: O14618. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Delivers copper to copper zinc superoxide dismutase (SOD1). |
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| Cofactor: | |
Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Evidence={ECO:0007744|PDB:2RSQ}; Note=Binds 2 copper ions per subunit. {ECO:0007744|PDB:2RSQ}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:10677207}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:10677207}; |
| Subunit: | |
Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4. {ECO:0000269|PubMed:10677207, ECO:0000269|PubMed:20154138, ECO:0000269|PubMed:20595380, ECO:0000269|PubMed:22508683, ECO:0000269|PubMed:23625804, ECO:0000269|PubMed:9726962}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:9726962}. |
| Tissue specificity: | |
Ubiquitous. |
| Ptm: | |
Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241. {ECO:0000269|PubMed:20154138}. |
| Similarity: | |
In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.