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UniProt functional annotation for Q15013 | ||
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| UniProt code: Q15013. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000269|PubMed:18022368}. |
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| Subunit: | |
Interacts with MAD2L1. {ECO:0000269|PubMed:12456649, ECO:0000269|PubMed:18022368}. |
| Subcellular location: | |
Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle. |
| Developmental stage: | |
During the cell cycle, levels increase and then remain constant until late mitosis after which they drop. {ECO:0000269|PubMed:12456649}. |
| Similarity: | |
Belongs to the MAD2L1BP family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAG59665.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.