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UniProt functional annotation for O15460 | ||
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| UniProt code: O15460. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. |
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| Catalytic activity: | |
Reaction=2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]; Xref=Rhea:RHEA:18945, Rhea:RHEA- COMP:11676, Rhea:RHEA-COMP:11680, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:61965; EC=1.14.11.2; |
| Cofactor: | |
Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000255|PROSITE-ProRule:PRU00805}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000255|PROSITE- ProRule:PRU00805}; |
| Cofactor: | |
Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence={ECO:0000250}; |
| Subunit: | |
Heterotetramer of two alpha-2 chains and two beta chains (the beta chain is the multi-functional PDI). |
| Subcellular location: | |
Endoplasmic reticulum lumen. |
| Disease: | |
Myopia 25, autosomal dominant (MYP25) [MIM:617238]: A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. {ECO:0000269|PubMed:25741866}. Note=The disease is caused by variants affecting the gene represented in this entry. |
| Similarity: | |
Belongs to the P4HA family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.