PDBsum entry 6ec0

Protein fibril

PDB id: 6ec0

Contents

Protein chains

107 a.a.

102 a.a.

Metals

_CO ×2

_NI ×2

_CD ×4

Waters ×35

PDB id:

6ec0

Name:

Protein fibril

Title:

Crystal structure of the wild-type heterocomplex between coil 1b domains of human intermediate filament proteins keratin 1 (krt1) and keratin 10 (krt10)

Structure:

Keratin 1. Chain: a. Engineered: yes. Other_details: coil 1b domain of human keratin 1 (krt1). Keratin, type i cytoskeletal 10. Chain: b. Synonym: cytokeratin-10,ck-10,keratin-10,k10. Engineered: yes. Other_details: gly-ser at n-terminus following his-tag cleavagecoil

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: krt1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: krt10, kpp.

Resolution:

2.98Å R-factor: 0.282 R-free: 0.300

Authors:

S.A.Eldirany,I.B.Lomakin,C.G.Bunick

Key ref:

S.A.Eldirany et al. Human keratin 1/10-1b tetramer structures reveal a knob-Pocket mechanism in intermediate filament assemb. Embo j, . PubMed id: 31036554

Date:

07-Aug-18 Release date: 15-May-19

Protein chain

H6VRG1  (H6VRG1_HUMAN) -  Keratin, type II cytoskeletal 1 from Homo sapiens

Seq: 645 a.a.

Struc: 107 a.a.*

Protein chain

P13645  (K1C10_HUMAN) -  Keratin, type I cytoskeletal 10 from Homo sapiens

Seq: 584 a.a.

Struc: 102 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.?