UniProt functional annotation for Q86T24



	UniProt functional annotation for Q86T24

UniProt code: Q86T24.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). {ECO:0000269|PubMed:11445535, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15548582, ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:23251453}.

Subunit: Self-associates. Interacts with CTNND2 (By similarity). Interacts with CTNND1, and this interaction inhibits binding to both methylated and non-methylated DNA. Interacts with NCOR1. Interacts with KPNA2/RCH1, which may mediate nuclear import of this protein. Interacts with CBFA2T3. {ECO:0000250|UniProtKB:Q8BN78, ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15564377, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:23251453}.

Subcellular location: Nucleus {ECO:0000269|PubMed:15781635, ECO:0000269|PubMed:16354688}. Cytoplasm {ECO:0000269|PubMed:15781635}. Note=Also cytoplasmic in cells grown at high densities.

Tissue specificity: Expressed in vascular endothelium. {ECO:0000269|PubMed:14699141}.

Induction: Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure. {ECO:0000269|PubMed:14699141}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). {ECO:0000269\|PubMed:11445535, ECO:0000269\|PubMed:14527417, ECO:0000269\|PubMed:15548582, ECO:0000269\|PubMed:15817151, ECO:0000269\|PubMed:16354688, ECO:0000269\|PubMed:23251453}.


Subunit:		Self-associates. Interacts with CTNND2 (By similarity). Interacts with CTNND1, and this interaction inhibits binding to both methylated and non-methylated DNA. Interacts with NCOR1. Interacts with KPNA2/RCH1, which may mediate nuclear import of this protein. Interacts with CBFA2T3. {ECO:0000250\|UniProtKB:Q8BN78, ECO:0000269\|PubMed:10207085, ECO:0000269\|PubMed:14527417, ECO:0000269\|PubMed:15564377, ECO:0000269\|PubMed:16354688, ECO:0000269\|PubMed:23251453}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:15781635, ECO:0000269\|PubMed:16354688}. Cytoplasm {ECO:0000269\|PubMed:15781635}. Note=Also cytoplasmic in cells grown at high densities.
Tissue specificity:		Expressed in vascular endothelium. {ECO:0000269\|PubMed:14699141}.
Induction:		Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure. {ECO:0000269\|PubMed:14699141}.