UniProt functional annotation for P43354



	UniProt functional annotation for P43354

UniProt code: P43354.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250, ECO:0000269|PubMed:17184956}.

Subunit: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By similarity). {ECO:0000250}.

Subcellular location: Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization.

Tissue specificity: Expressed in a number of cell lines of T-cell, B- cell and fibroblast origin. Strong expression in brain tissue.

Developmental stage: Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.

Domain: the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding site for coactivators (PubMed:12774125). {ECO:0000269|PubMed:12774125}.

Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250, ECO:0000269\|PubMed:17184956}.


Subunit:		Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By similarity). {ECO:0000250}.
Subcellular location:		Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization.
Tissue specificity:		Expressed in a number of cell lines of T-cell, B- cell and fibroblast origin. Strong expression in brain tissue.
Developmental stage:		Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.
Domain:		the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding site for coactivators (PubMed:12774125). {ECO:0000269\|PubMed:12774125}.
Similarity:		Belongs to the nuclear hormone receptor family. NR4 subfamily. {ECO:0000305}.