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UniProt functional annotation for P40261 | ||
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| UniProt code: P40261. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. |
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| Catalytic activity: | |
Reaction=nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:23884, ChEBI:CHEBI:16797, ChEBI:CHEBI:17154, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.1; |
| Subunit: | |
Monomer. {ECO:0000269|Ref.8}. |
| Subcellular location: | |
Cytoplasm. |
| Tissue specificity: | |
Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas. |
| Similarity: | |
Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.