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UniProt functional annotation for Q53U08 | ||
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| UniProt code: Q53U08. |
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| Organism: | |
Streptomyces fradiae (Streptomyces roseoflavus). |
| Taxonomy: | |
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces. |
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| Function: | |
6'-oxoglucosaminyl:L-glutamate aminotransferase that catalyzes pyridoxal-5'-phosphate-mediated transamination for the conversion of paromamine to neamine in the biosynthetic pathway of neomycin. Also able to catalyze deamination at C-6''' of neomycin. {ECO:0000269|PubMed:17206729, ECO:0000269|PubMed:21689223}. |
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| Catalytic activity: | |
Reaction=2-oxoglutarate + neomycin C = 6'''-deamino-6'''-oxoneomycin C + L-glutamate; Xref=Rhea:RHEA:33959, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:65068, ChEBI:CHEBI:65077; EC=2.6.1.95; Evidence={ECO:0000269|PubMed:17206729}; |
| Catalytic activity: | |
Reaction=2-oxoglutarate + neamine = 6'-oxoparomamine + L-glutamate; Xref=Rhea:RHEA:34039, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:65016, ChEBI:CHEBI:65076; EC=2.6.1.93; Evidence={ECO:0000269|PubMed:17206729}; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:17206729}; |
| Pathway: | |
Antibiotic biosynthesis; neomycin biosynthesis. {ECO:0000269|PubMed:17206729}. |
| Similarity: | |
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.