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UniProt functional annotation for Q7Z2D0 | ||
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| UniProt code: Q7Z2D0. |
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| Organism: | |
Plasmodium falciparum (malaria parasite P. falciparum). |
| Taxonomy: | |
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania). |
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| Function: | |
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. {ECO:0000256|RuleBase:RU362094}. |
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| Catalytic activity: | |
Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185, ECO:0000256|RuleBase:RU362094}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00001913}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; |
| Subunit: | |
Homodimer. {ECO:0000256|RuleBase:RU362094}. |
| Similarity: | |
Belongs to the type II topoisomerase family. {ECO:0000256|ARBA:ARBA00011080, ECO:0000256|RuleBase:RU362094}. |
Annotations taken from UniProtKB at the EBI.