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UniProt functional annotation for Q920Q2 | ||
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| UniProt code: Q920Q2. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. {ECO:0000269|PubMed:11711549}. |
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| Subunit: | |
Interacts with FAAP20 (By similarity). Monomer. Interacts with the DNA polymerase zeta which is composed of REV3L and MAD2L2; the interaction with MAD2L2 is direct and requires that REV3L is in its closed conformation. Interacts with POLH, POLI and POLK. {ECO:0000250, ECO:0000269|PubMed:11711549, ECO:0000269|PubMed:14657033}. |
| Subcellular location: | |
Nucleus {ECO:0000305}. |
| Tissue specificity: | |
Ubiquitous. {ECO:0000269|PubMed:11711549}. |
| Domain: | |
The C-terminal domain is necessary for protein interactions. |
| Similarity: | |
Belongs to the DNA polymerase type-Y family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.