|
|
||
|
|
|
|
|
UniProt functional annotation for O08967 | ||
|
|
|
|
|
|
||
| UniProt code: O08967. |
|
||
| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
|
||
|
||
| Function: | |
Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (PubMed:18042453). Plays a role in the epithelial polarization (PubMed:20080746). {ECO:0000269|PubMed:18042453, ECO:0000269|PubMed:20080746}. |
|
||
| Subunit: | |
Interacts with TAMALIN. Interacts with FRMD4A (PubMed:20080746). Interacts with FRMD4B (PubMed:20080746). {ECO:0000269|PubMed:10828067, ECO:0000269|PubMed:10983984, ECO:0000269|PubMed:10983985, ECO:0000269|PubMed:15359279, ECO:0000269|PubMed:18042453, ECO:0000269|PubMed:20080746}. |
| Subcellular location: | |
Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:18042453}; Peripheral membrane protein {ECO:0000269|PubMed:18042453}. Cell junction, adherens junction {ECO:0000269|PubMed:20080746}. Cell junction, tight junction {ECO:0000269|PubMed:20080746}. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate. |
| Domain: | |
Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate. |
| Domain: | |
Autoinhibited by its C-terminal basic region. |
Annotations taken from UniProtKB at the EBI.