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UniProt functional annotation for O94788 | ||
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| UniProt code: O94788. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Converts retinaldehyde to retinoic acid (PubMed:29240402). Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral (By similarity). {ECO:0000250|UniProtKB:Q63639, ECO:0000269|PubMed:29240402}. |
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| Catalytic activity: | |
Reaction=H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate; Xref=Rhea:RHEA:16177, ChEBI:CHEBI:15035, ChEBI:CHEBI:15036, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.36; Evidence={ECO:0000269|PubMed:29240402}; |
| Pathway: | |
Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:29240402}. |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:29240402}. |
| Subcellular location: | |
Cytoplasm. |
| Similarity: | |
Belongs to the aldehyde dehydrogenase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.