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UniProt functional annotation for P9WH13 | ||
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| UniProt code: P9WH13. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. {ECO:0000269|PubMed:17784859, ECO:0000269|PubMed:9084178}. |
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| Catalytic activity: | |
Reaction=alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose; Xref=Rhea:RHEA:15225, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37568, ChEBI:CHEBI:57477, ChEBI:CHEBI:58601; EC=2.7.7.24; Evidence={ECO:0000269|PubMed:9084178}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250}; |
| Pathway: | |
Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. |
| Similarity: | |
Belongs to the glucose-1-phosphate thymidylyltransferase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.