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UniProt functional annotation for Q9BW62 | ||
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| UniProt code: Q9BW62. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule- severing activity in vitro (PubMed:26929214). {ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}. |
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| Catalytic activity: | |
Reaction=n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_03024}; |
| Subunit: | |
Interacts with KATNB1 and KATNBL1. {ECO:0000269|PubMed:26929214}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton {ECO:0000255|HAMAP- Rule:MF_03024, ECO:0000269|PubMed:22654668}. Cytoplasm {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26929214}. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). {ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}. |
| Tissue specificity: | |
Expressed in testis, restricted to Sertoli cells (at protein level). {ECO:0000269|PubMed:22654668}. |
| Similarity: | |
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily. {ECO:0000255|HAMAP-Rule:MF_03024}. |
Annotations taken from UniProtKB at the EBI.