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UniProt functional annotation for P25105 | ||
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| UniProt code: P25105. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:1281995, ECO:0000269|PubMed:1374385, ECO:0000269|PubMed:1656963, ECO:0000269|PubMed:1657923}. |
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| Subunit: | |
Interacts with ARRB1. {ECO:0000269|PubMed:16709866}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:1374385}; Multi-pass membrane protein {ECO:0000269|PubMed:1374385}. |
| Tissue specificity: | |
Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes. {ECO:0000269|PubMed:1281995, ECO:0000269|PubMed:1656963, ECO:0000269|PubMed:1657923}. |
| Induction: | |
By CSF2/GM-CSF, IL5/interleukin-5 and n-butyrate. {ECO:0000269|PubMed:1657923}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
Annotations taken from UniProtKB at the EBI.