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UniProt functional annotation for P53927 | ||
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| UniProt code: P53927. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Involved in the biogenesis of the 60S ribosomal subunit. Required for pre-rRNA processing and cytokinesis. Associates with the precursors of the 25S and 5.8S rRNAs. {ECO:0000269|PubMed:11583614, ECO:0000269|PubMed:14657029}. |
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| Subunit: | |
Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. {ECO:0000269|PubMed:11583614, ECO:0000269|PubMed:14657029, ECO:0000269|PubMed:15100437}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:11583614}. Nucleus, nucleolus {ECO:0000269|PubMed:10953080, ECO:0000269|PubMed:11583614}. |
| Disruption phenotype: | |
Essential gene. Abrupt growth arrest prior to substantial depletion of ribosomal subunits. Fails to synthesize the 25S and 5.8S rRNA components of the 60S ribosomal subunit, and exonucleolytic 5' processing of 5.8S rRNA is strongly inhibited. Arrests at cytokinesis and fails to assemble a contractile actin ring at the bud neck. {ECO:0000269|PubMed:10953080, ECO:0000269|PubMed:14657029}. |
| Miscellaneous: | |
Present with 4280 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
Annotations taken from UniProtKB at the EBI.