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PDBsum entry 5xmx
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Transcription/inhibitor
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PDB id
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5xmx
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References listed in PDB file
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Key reference
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Title
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Novel highly selective peroxisome proliferator-Activated receptor δ (pparδ) modulators with pharmacokinetic properties suitable for once-Daily oral dosing.
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Authors
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B.Lagu,
A.F.Kluge,
R.A.Fredenburg,
E.Tozzo,
R.S.Senaiar,
M.Jaleel,
S.K.Panigrahi,
N.K.Tiwari,
N.R.Krishnamurthy,
T.Takahashi,
M.A.Patane.
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Ref.
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Bioorg Med Chem Lett, 2017,
27,
5230-5234.
[DOI no: ]
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PubMed id
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Abstract
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Optimization of benzamide PPARδ modulator 1 led to
(E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy)-4-methylhex-4-enoic
acid (18), a potent selective PPARδ modulator with significantly improved
exposure in multiple species following oral administration.
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