UniProt functional annotation for P47871



	UniProt functional annotation for P47871

UniProt code: P47871.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}; Multi-pass membrane protein {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}. Note=Is rapidly internalized after ligand-binding. {ECO:0000269|PubMed:9287038}.

Ptm: Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding. {ECO:0000269|PubMed:9287038}.

Similarity: Belongs to the G-protein coupled receptor 2 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269\|PubMed:19657311, ECO:0000269\|PubMed:22908259, ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451, ECO:0000269\|PubMed:7507321, ECO:0000269\|PubMed:9287038}.


Subcellular location:		Cell membrane {ECO:0000269\|PubMed:19657311, ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451, ECO:0000269\|PubMed:7507321, ECO:0000269\|PubMed:9287038}; Multi-pass membrane protein {ECO:0000269\|PubMed:19657311, ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451, ECO:0000269\|PubMed:7507321, ECO:0000269\|PubMed:9287038}. Note=Is rapidly internalized after ligand-binding. {ECO:0000269\|PubMed:9287038}.
Ptm:		Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding. {ECO:0000269\|PubMed:9287038}.
Similarity:		Belongs to the G-protein coupled receptor 2 family. {ECO:0000305}.