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UniProt functional annotation for P26951 | ||
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| UniProt code: P26951. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
This is a receptor for interleukin-3. |
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| Subunit: | |
Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Domain: | |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. |
| Domain: | |
The box 1 motif is required for JAK interaction and/or activation. |
| Miscellaneous: | |
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. |
| Similarity: | |
Belongs to the type I cytokine receptor family. Type 5 subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAA08393.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.